Correlation of serum lipid in infective disease and infective hepatitis

ABSTRACT

Dylipidaemia is a disorder of lipid metabolism. It is either primary due to familial, genetic factors or secondary due to environmental metabolic, infection or drugs. In this study, we evaluated the prevalence of dyslipidemia in 78 patients with infectious disease and infective hepatitis. 78 patients with acute infection and 20 controls were classified into group I 24 patients with gram positive Cocci, group II 24 patients with gram negative Bacilli, group III 30 patients with acute infectious hepatitis and group IV 20 normal as control. There were hyperlipidaemia with significant increase in cholesterol and triglycerides [P<0.001], alpha [P<0.05] and beta lipoproteins [P<0.01] and significant decrease in prebeta lipoprotein [P<0.001] in acute infectious hepatitis. A significant low level of prebeta lipoprotein is due to decrease synthesis by the liver during infection, hyperlipidemia is an index to the progress of the infection and APO E has physiological role in protection against lipo polysaccharide endo-toxemia and sepsis and can be used therapeutically