flunitrazepam [rohypnol] for minor anal surgery

ABSTRACT

Fifty patients subjected to minor anal surgery were anaesthetised by flunitrazepam and thiopentone and premidecated by atropine sulphate and Pethidine HCL. Pulse, blood pressure, heart, chest, and respiratory rate were assessed. Blood samples for pH and blood gas estimations were taken for 10 patients and meassured after the premedication, after flunitrazepam, thiopentone, and at the end of operation. Our results showed a significant rise in pulse rate after premedication, and insignificant changes after flunitrazepam and thiopentone. The respiratory rate decreased after premedication but showed a statistically evident change after flunitrazepam and thiopentovic pH and blood gas analysis did not reveal any significant changes during the whole procedure. Our results showed a potentiation of the residual effect of flunitrazepam, and a synergetic action of pethidine and thiopentone. Therefore, we could conclude that flunitrazepam in combination with thiopentone can produce a form of balanced anaesthesia suitable for surgical procedures of short duration