Effect of vanadium, radish and dill on some nutritional and biochemical parameters in diabetic rats

ABSTRACT

The present study was designed to investigate the effect of the vanadium pentaoxide and vegetables rich source in nadium as dill and radish on the nutritional status, some biochemical parameters and the histology of pancreas on streptozotocin induced diabetic rats. Forty-eight adult male rats, weighing 115 +/- 8 g rats were classified into control group and seven streptozotocin induced diabetic rat groups [untreated, treated with high, low vanadium, radish, dill, and low vanadium with dill or with radish groups]. The results revealed that, the untreated diabetic rat groups had a significant lower values of the final body weight, weight gain and its percentage, food intake, FER, insulin, triglyceride, AST/ALT ratio, total protein, globulin and HDL-c but significant increase in glucose, cholesterol, TG, LDL-c, urea and creatinine when compared with control group. The consumption of low vanadium with dill or radish to diabetic rat groups showed non significant difference in final body weight, weight gain and its percentage. food intake- FER, hemoglobin, PCV, cholesterol, TG, LDL-c, HDL-c, total protein, globulin, urea and creatinine, AST and ALT when compared with control group. Compared with untreated diabetic rats group, there were a significant increase in final body weight, weight gain, food intake, food efficiency ratio and globulin but significant decreased in cholesterol, LDL-c, urea and creatinine in all treated rats groups. Triglyceride increased in dill and radish groups. HDL-c decreased in dill group. High vanadium and low vanadium with dill or radish treated groups showed significant decreased in ALT and significant increased in AST/ALT ratio and total protein. There was non-significant difference in hemoglobin, packed cell volume, glucose, insulin and albumin among all treated rats group.lt is concluded that vanadium and its natural sources as dill or radish have hypoglycemic effect and beneficial for diabetic cases