Measuring of free endotoxin in alum-precipitated vaccine of haemorrhagic septicaemia by limulus amebocyte lysate test
Iranian Journal of Veterinary Research. 2007; 8 (1): 83-85
em Inglês
| IMEMR
| ID: emr-83137
ABSTRACT
Haemorrhagic septicaemia [HS] vaccine which is prepared in Razi Institute is used in endemic areas of Iran. Aluminum-hydroxide gel was used as adjuvant for preparing this vaccine. Post-vaccinal shock reactions were the main complaint after use of this vaccine. In a previous study, we could improve the vaccine by alum-precipitation Pasteurella multocida cells and removing the liquid phase. In this study, the amount of free endotoxin in aluminum-hydroxide and alum-HS vaccines was determined. It was found that endotoxin level was considerably decreased from 0.22 EU/ml to 0.03 EU/ml after alum-precipitation
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Vacinas
/
Resposta ao Choque Térmico
/
Endotoxinas
/
Teste do Limulus
Limite:
Animais
Idioma:
Inglês
Revista:
Iran. J. Vet. Res.
Ano de publicação:
2007
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