Efficacy of Adcon-L gel or Healon-GV in epidural fibrosis after lumbar microdiscectomy

ABSTRACT

To evaluate the efficacy of anti-adhesion barrier agents following lumbar microdiscectomy. Healon GV or Adcon-L was applied to a laminectomy defect overlying the duramater in 60 patients assigned to 3 randomized groups Group I - Adcon-L [n=21], Group II - Healon GV [n=21], and Group III - control group, no adhesion barrier used [n=18]. We conducted this study between 2004 and 2006 at Selcuk University, Konya, Turkey. No significant difference was found between the 3 groups either in the outcome measurements according to visual analogue score and the Oswestry Disability Index or in the radiological evaluation of epidural fibrosis by application of those anti-adhesion barrier agents. When comparing group III with groups I and II, we could not find a statistically significant difference in the clinical results and in the outcome measures [p>0.01]. The epidural application of popular anti-adhesion barriers, after lumbar microdiscectomy was not found to be effective regarding outcome measures in human spinal surgery