Comparison of predictive value of 8, 12 and 24- hour proteinuria in pre-eclampsia

ABSTRACT

Hypertensive disorders of pregnancy are common major complications of pregnancy and are responsible for significant morbidity and mortality in the fetus the newborn infant and the mother. The objective of this study was to determine if a patients' eight and/or 12-hour urine total protein values correlate with the 24-hour value to confirm the diagnosis of preeclampsia. The study population included 57 patients with hypertensive disorders of pregnancy. Patients" urine was collected over 24 hours with the first 8 hours, next 4 hours, and remaining 12 hours in separate containers. The urine volume and total protein were measured in the 8, 12, and 24-hour samples. The 8 and 12 hour results were compared to the results by use of single regression analysis. Of the 57 patients, 49 had no proteiuria, six had mild proteinuria, and two had severe proteinuria. The results of the 8- hour sample correlated with those of the 24- hour sample for patients with mild [P<0.05] and severe disease [P<0.05]. The 12 hour sample correlated with the 24-hour sample for patients with no disease [p<0.02], mild proteinuria [P<0.02], and severe proteinuria [p<0.01]. Total protein values for 8- and 12- hour urine samples correlate positively with values for 24-hour samples for patients with proteinuria. The results for 12 and 24 hour samples correlate for patients without proteinuria