In vitro synergy of fusidic acid and amikacin against methicillin resistant staphlococcus aureus
Pakistan Journal of Medical Sciences. 2007; 23 (2): 245-248
em Inglês
| IMEMR
| ID: emr-84793
ABSTRACT
To test in vitro combination of fusidic acid and amikacin against infections caused by methicillin resistant Staphlococus aureus [MRSA]. In vitro study conducted in Department of Pharmacology and Microbiology, Dr. Ziauddin Medical University. The duration of study was March 2004- February 2005. Antibiotic susceptibility testing was done by Kirby Bauer"s disc diffusion method and by minimum inhibitory concentration [MIC] by broth macrodilution and checkerboard technique for synergy. FIC [fractional inhibitory concentrations] were calculated. MIC of fusidic acid was 0.03-1micro g/ml and amikacin 0.5-16 micro g/ml respectively. The combination of these demonstrated synergy. Evidence of synergy correlated directly with the MICs of fusidic acid and amikacin. Combination therapy with fusidic acid and amikacin may be a reasonable alternative in the treatment of infections caused by MRSA isolates and encourages clinical evaluation
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Resistência Microbiana a Medicamentos
/
Amicacina
/
Vancomicina
/
Testes de Sensibilidade Microbiana
/
Resistência a Meticilina
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Sinergismo Farmacológico
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Ácido Fusídico
Idioma:
Inglês
Revista:
Pak. J. Med. Sci.
Ano de publicação:
2007
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