[TSH-secreting adenoma: Difficulty in management and review of literature-about one case]

ABSTRACT

TSH-secreting adenomas are rare; they represent less than 2 or 3% of all pituitary adenomas. We report a case of TSH-secreting adenoma in a 52 year old man revealed by cardiac arrythmia. The diagnosis was made in presence of hyperthyroidism with a TSH in the upper limit of normal value, with an increase in the alpha sub-unit and with the presence on the MRI of a pituitary macroadenoma. The patient was treated with somatostatin analogues before transphenoidal surgery. TSH-secreting adenomas are classically revealed by hyperthyroidisni with inappropriate secretion of TSH and a pituitary adenoma. Transphenoidal surgery is the recommended treatment but the results are not always satisfactory because most adenomas are invasive macroadenomas. Somatostatin analogues improve management and prognosis of these adenomas