role of cinnamon and curcumin in enhancing antioxidants activity in aspirin induced hepatotoxic rats

ABSTRACT

This study was undertaken to investigate the putative antioxidant activity of cinnamon and curcumin on aspirin induced hepatotoxicity in male albino rats Aspirin [in a form of acetylsalicylic acid] was administrated to rats through the diet 4mg% for 30 days [G2] on the other hand, cinnamon and/or curcumin were administered to rats in concentration of 5% as seen in groups [G3, G4, G5]. Obtained results of G2 announced a significantly elevated [p<0.01] serum levels of aspartate transaminase [AST],alanine transaminase [ALT], alkaline phosphatase [ALP], and bilirubin as compared to the control group. On the other hand, aspirin administration resulted in significant reduction [p<0.01] in the level of total protein compared to the control group. In the liver, significantly elevated levels [p<0.01] of malondialdehyde [MDA] was observed. The analysis of antioxidant defense system [superoxide dismutase [SOD] and phospholipids hydroperoxide glutathione peroxidase [GPx-4]] revealed lower activities of these antioxidant enzymes in the liver of aspirin administered rats. All these results reported the incidence of hepatotoxicity. When rats with aspirin induced hepatotoxicity were treated with cinnamon and/or curcumin, [G3,G4,G5], serum ALT, AST, ALP, total serum protein and bilirubin levels reverted to near normal while hepatic concentration of SOD and GPx-4 were significantly increased [p<0.01], and that of MDA significantly lowered [p<0.01], when compared to aspirin administered untreated rats. These results suggest that, cinnamon and curcumin were able to significantly alleviate the hepatotoxicity induced by aspirin in rats