Al-Azhar Medical Journal. 2008; 37 (3): 453-460
em Inglês
| IMEMR
| ID: emr-85684
ABSTRACT
Helicobacter [H] pylori was found to be present in a high percentage of cirrhotic patients, H. pylori colonized stomach contain more apoptotic epithelial cells than normal stomach. The aim of this work was to evaluate efficacy and safety of a triple therapy [Lanzoprazole, Tinidazole and Clarithromycin] in eradication of H. pylori and the effect of H. pylori eradication on the gastric mucosal apoptosis among cirrhotic patients. Fifty patients were classified into two groups Group [I] Twenty-five patients with liver cirrhosis and H. pylori positive. Group [II] Twenty-five non-cirrhotic patients with manifestations of peptic disease and H. pylori positive. All patients were enrolled in a 7 days triple therapy with Lanzoprazole [30 mg], Tinidazole [500 mg] and Clarithromycin [250 mg], each twice / day. Apoptosis was determined before and after 4-6 weeks of H. pylori eradications. Eradication of H. pylori was achieved in 21 patients [84%] in cirrhotic patients, while it was eradicated in 22 patients [88%] in non-cirrhotic patients. The highest apoptotic figure was recorded in-group I before eradication [14.62 +/- 2.08]; it is significantly decreased after eradication of H. pylori [4.34 +/- 1.34, P <0.01]. In-group II a significant reduction of the apoptotic index from [12.2 +/- 10.6 to 2.75 +/- 1.06, P <0.01] after eradication of H. pylori. In conclusion, one-week triple therapy by Lanzoprazole, Tinidazole and Clarithromycin was effective and safe in eradication of the H. pylori in cirrhotic and non-cirrhotic patients. Hepatic cirrhosis increased gastric apoptosis. H. pylori eradication reduced gastric apoptosis among cirrhotic and non-cirrhotic patients
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Tinidazol
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Resultado do Tratamento
/
Misoprostol
/
Claritromicina
/
Apoptose
/
Combinação de Medicamentos
/
Mucosa Gástrica
/
Histologia
Limite:
Humanos
Idioma:
Inglês
Revista:
Al-Azhar Med. J.
Ano de publicação:
2008
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