Anti-genotoxic effect of vitamin E administration in acrylamide intoxicated rat bone marrow cells

ABSTRACT

This study aims to investigate the effect of oral administration of vitamin E [VE, 300 mg/kg, oral intubation daily for 21 consecutive days] to normal and acrylamide-intoxicated [ACR, 25 mg/kg daily for 21 consecutive days] rats. Bone marrow was used to monitor the changes in micronucleus [MN] incidence and modulating the genotoxic effects of gavaged ACR. Treatment of rats with acrylamide [ACR] significantly elevated the frequency of bone marrow MN. Moreover, VE administration decreased the MN frequency to be near the control values; suggesting the ameliorative effect of VE against ACR toxicity