Synthesis of some novel 1, 3, 5-trisubstituted [1,2,4] triazole derivatives as potential antibacterial agents

ABSTRACT

In the present work, some new l,3,5-trisiubstituted [l,2,4]-triazole derivatives and their Schiff's bases were synthesized. The chemical structure of the target compounds was confirmed by IR, [1]H-NMR, [13]C-NMR, FAB-MS, EI-HRMS spectra and elemental analyses. The title compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative ones using ampicillin and nalidixic acid as reference drugs. Some of them showed antibacterial activity more significant than the reference drugs