Inclusion complexes of meloxicam and cyclodextrins
Bulletin of the National Research Centre. 2008; 33 (1): 35-50
em Inglês
| IMEMR
| ID: emr-86067
ABSTRACT
The interaction of meloxicam with cyclodextrins was investigated. The formation of a 11 inclusion complex with hydroxy propyl beta-cyclodextrin and a 12 complex with beta-cyclodextrin was established. Characterization was conducted by FTIR spectroscopy, XRD, TGA and [1]H-NMR spectroscopy studies. The solubility increased by increasing pH from 1.2-6.8. The dissolution rates revealed enhanced dissolution properties of the cyclodextrin complexes compared to the drug. The partition between n-octanol and 0.1 N HCI or Mclvaine's citric acid phosphate buffer, revealed that the partition coefficient of meloxicam is higher compared to complexes with cyclodextrins. The present study denotes the capability of forming a more soluble product of meloxicam, at physiologic pH, via complexation with cyclodextrins which would result in enhanced bioavailability and improved efficacy
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Tiazinas
/
Tiazóis
/
Espectroscopia de Ressonância Magnética
/
Inibidores de Ciclo-Oxigenase
/
Ciclodextrinas
/
Combinação de Medicamentos
Idioma:
Inglês
Revista:
Bull. Natl. Res. Cent.
Ano de publicação:
2008
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