Study of antinociceptive and antioxidant activities of [Hyptis capitata, Litsea glutinosa and Vernonia patula three medicinal plants of Bangladesh

ABSTRACT

A number of Bangladeshi medicinal plants have been reported to possess antinociceptive and antioxidant activities. Many of which have been used in the preparations of the Unani and Ayurvedic traditional medicine. As a part of our on-going research for exploring the bioactivities of Bangladeshi medicinal plants. Bala [llyptis capitata], Kukur-Chita [Litsea glutinosa], and Bonmulo [Vernonia patula] have been studied for their antinociceptive and antioxidant activity together with the phytochemicals namely, alkaloids, flavonoids. steroids, and tannins. Except for L. glutinosa, the ethanolic extracts of V. patula and H. capitata significantly reduced the acetic acid induced writhing in mice. In DPPH free radical scavenging assay all the extracts showed mild to moderate activity, in which IC[50] of H. capitata and V. patula were > 100 micro g/ml and that of L. glutinosa was > 500 micro g/ml. All the extracts showed positive tests with Dragendorffs. Braemer's, and Liebermann-Burchardt's reagent but gave negative result with Shinoda's reagents, except for V. patula