[Comparison of pregnancy and hyperstimulation syndrome rate with GnRH agonist and HCG in ovation induction of PCOS]

ABSTRACT

Infertile women with induction ovulation that have appropriate follicules, need LH surge to release eggs, this is done routinely by HCG. This study designed to compare the pregnancy rate and hyper stimulation syndrome in PCOS patients with GnRH agonist instead of HCG. This descriptive study performed from 2003 to 2004 on 130 infertile patients with PCOS at Babol Infertility Center, Babol, Iran. This study was approved by the local committee of medical ethics. After induction ovulation if patients had 2 Follicules more than 16 mm or 3 folliculs more than 14 mm, we randomly used HCG or GnRH agonist for LH surge. The pregnancy rate and hyperstimulation syndrome evaluated. Data analyzed by SPSS. There were79 patients in HCG group and 44 patients in GnRH agonist group. There was no significante difference between HCG and GnRH agonist group, with regard to the mean age, infertility duration, number of HCG injection, body mass index and type of infertility [p>0.05]. Over all 7[8.9%] patients in HCG group and 3[6.8%] in GnRH agonist group had ovarian hyperstimulation syndrome [p= 0.49]. There was pregnancy in 35 [44.3%] patients of HCG group and in 20 [45.5%] patients of GnRH agonist group [p= 0.526]. There was no significant difference in the rate of pregnancy and ovarian hyperstimulation in patients with polycystic ovary, having induction ovulation with HCG and GnRH agonist. So it can be concluded we can say that GnRH can be used instead of HCG for doing LH surge in PCO patients