Synthesis and anticholinergic activity of 8-methyl-8-azabicyclo [321] octanes analogs of atropine
Egyptian Journal of Pharmaceutical Sciences. 1987; 28 (1-4): 149-61
em Inglês
| IMEMR
| ID: emr-8706
ABSTRACT
Ten esters derived from 3-hydroxy-8-methyl-8-azabicycle [3.2.1] octane and the corresponding methiodin salts were synthesised. The novel compounds were evaluated for anti-cholinergic activity using rabbit duodenum assay. Among these compounds, 8-methyl-8-azabicycle [3.2.1.] loct-3-y1-3-carbisobutoxy-3- phenyl-propionate [12] was found to be the most effective antispasmodic, comparable in potency to atropine
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Parassimpatolíticos
/
Octanos
Idioma:
Inglês
Revista:
Egypt. J. Pharm. Sci.
Ano de publicação:
1987
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