Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs
Iranian Journal of Veterinary Research. 2008; 9 (3): 266-270
em Inglês
| IMEMR
| ID: emr-87314
ABSTRACT
Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride [50 mg/kg] to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Non-compartmental analysis of the data indicated that tetracycline has a half-life of 4.4 h, a body clearance of around 0.7 ml/kg. min and a volume of distribution of about 0.3 L/kg. The pharmacokinetics of tetracycline found in this study is favourable for therapeutic use in the dog
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Espectrometria de Fluorescência
/
Tetraciclina
/
Cães
/
Injeções Intravenosas
Limite:
Animais
Idioma:
Inglês
Revista:
Iran. J. Vet. Res.
Ano de publicação:
2008
Similares
MEDLINE
...
LILACS
LIS