Evaluation of spontaneous abortion and multiple gestation rates in patients undergoing ovulation induction and intrauterine insemination

ABSTRACT

Cohort analytic study to assess risks of spontaneous abortion and multiple gestations in patients undergoing induction of ovulation. In this study we compared the spontaneous abortion and multiple gestation rates of 361 cases that they were undergoing ovulation induction with clomiphene citrate alone or with human menopausal gonadotropin and they were candid for intrauterine insemination with a control group consisting of 350 cases who were conceived naturally. We matched the two groups with regard to age and weight. Abortion considered as spontaneous termination of pregnancy below 20 week of pregnancy and multiple gestation diagnosis was based on sonography in any time during pregnancy. We used chi-square test for statistical analysis and determination of differences between groups. Intrauterine insemination was performed in 361 cases and pregnancy happened in 70 cases [19/4%] of study group. The spontaneous abortion happened in 10 cases [14/2] and in control group among 350 cases spontaneous abortion happened in 50 cases [14/2]. Statistical analysis with chi-square test revealed that there isn, t Significant statistical difference between the study group and control group. In regard to multiple gestations there were 1 cases of multiple gestations in study Group. Six cases were twin and one of them was quadruplet. In control group there were 6 cases of multiple pregnancies, 5 cases were twin and one of them was triplet. Statistical analysis with chi-square test showed that there is a significant statistical difference between the study group and control group. In this study there was not significant statistical difference in abortion rate between the patients who they were undergoing ovulation induction/intrauterine insemination and normal fertile group but there was significant statistical difference in multiple gestations between two groups