Modulatory effects of thymoquinone on the toxicity induced by imidacloprid in albino rat, Rattus norvegicus

ABSTRACT

The possible modulatory potential of thymoquinone [TQ] against imidacloprid [IC] induced toxicity was examined in male albino rats. One hundred and forty four adult male albino rats, Rattus norvegicus, were allocated into six groups, three groups are control and the other three groups are treated. IC was given orally at a dose of 1/100 LD50 / day for 4 weeks, with or without pretreatment of TQ that given weekly as a single i.p. injection at a dose of 1mg/kg.b.wt. Oral administration of IC significantly decreased RBC, Hb, Hct, ALP, and total protein, while increased AST, ALT, cholesterol, triglycerides, creatinine, and lipid peroxide. Recovery of haematological and biochemical changes was observed after TQ supplementation. It is concluded that TQ might alleviate disturbance in haematological and biochemical parameters induced by IC toxicity