Modulatory effects of thymoquinone on the histological changes induced by imidacloppid in albino rats

ABSTRACT

The possible modulatory effects of thymoquinone [TQ] against pathological changes induced by imidacloprid [IC] were examined using male albino rats. One hundred and forty four adult male albino rats [Rattus norvegicus] were allocated into six groups, one group is normal, two are control groups and the other are treated groups. IC was given orally at a dose of 1/100 LD 50/ day for 4 weeks, without TQ, before TQ, or with TQ [given as a single i.p. injection weekly at a dose of 1 mg/ kg.b.wt]. Histopathological studies of liver showed dense interstitial hemorrhage, pyknotic nuclei, and infiltration with leucocytes. Also, kidney sections of animals treated with IC insecticide showed clear proliferation, interstitial hemorrhage, and pyknotic nuclei in glomerular tissue. Furthermore, marked dilatation in renal tubules and urinary spaces were observed. Medullary tubules of the kidney showed interlobular hemorrhage. Partial recovery of histological changes was observed after TQ supplementation. It is concluded that TQ might alleviate histological alteration in the liver and kidney which are induced by IC