Male androgenetic alopecia treated with finasteride

ABSTRACT

Dihydrotestosterone causes micronization of scalp hair follicles, resulting in androgenetic alopecia. Finasteride inhibits type II 5alpha-reductase, thereby, decreasing the conversion of testosterone to dihydrotestosterone. To determine the efficacy of finasteride in male androgenetic alopecia. 16 men from 18-42yrs of age with moderate vertex pattern hair loss received 1mg finasteride daily for 2 yrs. Efficacy was determined by patients self assessments, investigator assessment and assessment of clinical photographs, safety was assessed by clinical analysis of adverse experience if any. After 6 months-1yr treatment, there was a significant improvement in patient, investigator and photographic assessment. Efficacy was improved and maintained throughout the second year of the study. Finasteride was generally well tolerated. In men with male pattern hair loss finasteride 1mg for 2 yrs slowed the progression of hair fall and increased hair growth