Relation between insulin level and bone mineral density in patients with type 2 diabetes mellitus

ABSTRACT

The aim of this work is to measure BMD in patients with type 2 diabetes mellitus and to correlate it with insulin level and insulin resistance. This study comprised 50 premenopausal women 40 type 2 diabetic patients [20 on insulin therapy and 20 or oral hypoglycemic drugs], 10, as a control group, which were healthy non diabetic women matched for age. All studied subjects were subjected to history taking, clinical examination, including weight, height, BMI and waist/hip ratio. Laboratory investigations including fasting and post prandial blood glucose levels, HbA1c, kidney functions, liver functions, urine analysis, lipid profile, serum calcium, phosphorus, alkaline phosphatase, and fasting insulin level. Bone mineral density [BMD] was measured using DEXA on left fore-arm using Lunar PIXI densitometer. Subjects with other diseases or using drugs that affect BMD were excluded. We found that there was no statistically significant difference in BMD between patients with type 2 diabetes mellitus and the control group [T-score was -0.3 in the diabetic group and T-score was -0.2 in the control group]. In patients with type 2 diabetes mellitus, there was a significant positive correlation between BMD and both insulin level [p value <0.05] and insulin resistance [p value <0.05]. There was no difference in BMD between type 2 diabetic patients and control group. There was a significant positive correlation between BMD with both insulin level and insulin resistance [HOMA] in patients with type 2 DM