Relation between maternal plasma concentration of serum endoglin in patients with IUGR and preeclampsia: correlation with doppler study

ABSTRACT

The aim of the study was to compare between the rise in serum endoglin [sEng] in pregnant women with normotensive IUGR and preeclamptic pregnant women with and without IUGR and to compare between serum placental growth factor [PIGF] and endoglin levels in serum of pregnant patients with IUGR. Prospective analytic comparative study. The study includes group [1] 17 cases with manifest preeclampsia without IUGR, group [2] 11 cases with preeclampsia and IUGR, group [3] 12 normotensive pregnancies with IUGR and 15 gestational age matched control. sEng and PIGF were determined by ELISA, Doppler examination of the umbilitcal vessels in the form of PI and S/D ratio were done. The three groups show significantly higher sEng concentration compared to the control group [32.2 +/- 6.0 ng/ml, 42.3 +/- 10.5 ng/ml, 24.5 +/- 7.1 ng/ml and 12.2 +/- 3.6 ng/ml in the 4 groups respectively, p<0.001]. The three groups showed significantly lower level of PIGF [45.4 +/- 20.4 pg/ml, 23.3 +/- 12.1 pg/ml, 73.1 +/- 54.7 pg/ml and 111.1 +/- 58.4 pg/ml in the 4 groups respectively. P<0.003]. There was no significant difference between sEng in the three groups. Significant difference was found for serum levels of PIGF between normotensive IUGR and the other 2 groups. There was a significant positive correlation between sEng levels and S/D ratio [r= .939 p< 0.001] and PI [r=.695 p<0.001] of the umbilical vessels in group of preeclampsia without IUGR and insignificant correlation between serum levels of PIGF and Doppler study of the umbilical vessels in the same group. sEng increased in all cases with placental pathology even in normotensive IUGR, while PIGF has the reverse relationship, it decreased in placental pathology with negative relationship with severity. The correlation between maternal serum levels of sEng and PIGF and Doppler ultrasound indices of umbilical arteries in pre-eclampsia and IUGR reflect the severity of the disorders