Evaluation of transforming growth factor alpha [TGFn] and tumor necrosis factor alpha [TGFn] in children with acute hepatitis

ABSTRACT

The present study included 60 children who were recruited from Pediatric Department of National Liver Institute [NLI], Menoufiya University and 20 apparently healthy children from the relatives of patients as a control group. Their ages ranged from 2 to 15 years, they were 49 males and 31 females. The studied children were divided according to their diagnosis into groups each of 20; Group [I] acute hepatitis, Group [II] acute fulminant hepatitis [F. H], Group [III] chronic hepatitis and Group [IV] control group. The mean level of both transforming growth factor alpha [TGF I] and tumor necrosis factor alpha [TNF I] were higher in group II [32.74 +/- 9.98 pg/mL and 116.41 +/- 49.70 pg/ml, respectively] more than the other groups and the difference was statistically highly significant [[P<0.001] and [<0.05], respectively]. The mean of level of [TGFD in FH survivors was [29.23 +/- 5.51pg/mL] compared to deceased ones [20.93 +/- 4.60 pg/mL] but the difference was statistically insignificant [p>0.05]. On the other hand the mean of [TNFI] in the deceased cases was 132.76 +/- 48.81pg/mL compared to 117.93 +/- 19.15pg/mL in survivors but the difference was statistically insignificant [P > 0.05]. Case fatality rate for all FH cases was 80%. In conclusion, the levels of both TGFI and TNFI are significantly higher in fulminant hepatitis more than acute hepatitis cases but with no significance in the progress of the disease. Further studies is recommended to uncover predictors that can differentiate between acute hepatitis and fulminant hepatitis and the progress of the disease