Pharmacokinetics of ciprofloxacin in normal rabbits and changes observed in induced dehydrated state
Pakistan Journal of Pharmaceutical Sciences. 2008; 21 (3): 225-229
em Inglês
| IMEMR
| ID: emr-89417
ABSTRACT
The pharmacokinetics of ciprofloxacin following oral administration of a single dose of 20mg/Kg body weight was investigated in normal rabbits and changes were observed in water-deprived rabbits. High performance liquid chromatographic method was employed for the determination of plasma concentration of ciprofloxacin. The mean plasma concentration and AUC [0-t] and AUC [0-inf] were significantly different between normal and dehydrated rabbits [P < 0.05], but the absorption rate, distribution rate, and elimination rate did not show any statistically significant difference. The results reflect a need for monitoring toxicity of ciprofloxacin in the water-deprived condition
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Coelhos
/
Ciprofloxacina
/
Cromatografia Líquida de Alta Pressão
/
Desidratação
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2008
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