Effect of compound 11 g as a novel selective cox-2 inhibitor on movement disorders in a rat model of parkinson's disease
Pakistan Journal of Medical Sciences. 2008; 24 (3): 436-441
em Inglês
| IMEMR
| ID: emr-89549
ABSTRACT
To test the effect of selective COX-2 inhibitors compound 11g on movement disorders of Parkinson's disease [PD]. In the study the rat Left substantia nigra pars compacta [SNc] has been destroyed using electrical Lesion [10 Sec; 1 mA DC] to generate PD model. Then 11g [2, 4mg/kg] and celecoxib a well known and standard COX-2 inhibitor [4, 8mg/kg] have been administrated orally to parkinsonian rats. Then the rigidity and locomotor activity of parkinsonian rats were evaluated. Both selective COX-2 inhibitors decreased the rigidity and improved the locomotor activity of parkinsonian rats P>O.05 as compared to the control groups. Based on the results of the locomotor activity and rigidity tests using parkinsonian rats, we found that compound 11g had remarkable rigidity-improving effect
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Doença de Parkinson
/
Pirazóis
/
Sulfonamidas
/
Substância Negra
/
Resultado do Tratamento
/
Modelos Animais
/
Traumatismos por Eletricidade
/
Transtornos dos Movimentos
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Med. Sci.
Ano de publicação:
2008
Similares
MEDLINE
...
LILACS
LIS