Pakistan Journal of Medical Sciences. 2008; 24 (4): 531-536
em Inglês
| IMEMR
| ID: emr-89571
ABSTRACT
This study determines the expression of latent membrane protein-1 [LMP- 1] in lymph nodes of patients with classic Hodgkin lymphoma [cHL] and its role in patients' survival. Specimen of 98 patients who had cHL was chosen and the samples were immunohistochemically stained with LMP-1 and Overall disease-free survival [DFS] was measured from the date of complete remission until the Relapse was confirmed by another lymph node biopsy. We investigated the expression of LMP-1 in outcome of patients with cHL. LMP-1 was detected in RS cells of cHL in twenty five out of ninety eight [25.5%] patients. LMP-1 expression was significantly more frequent in mixed cellularity, 46.7%, than nodular sclerosis, 15.4% [P= 0.005]. Patients with EBV-positive tumors had fewer DFS [22.6 vs. 25.9 mo], but the difference was not statistically significant [p=0.06]. Although in our study there is no relationship between age and LMP-1 expression. LMP-1 expression is associated with statistically different DFS in treated patients with cHL
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Doença de Hodgkin
/
Imuno-Histoquímica
/
Análise de Sobrevida
/
Proteínas da Matriz Viral
/
Estudos Transversais
/
Intervalo Livre de Doença
/
Infecções por Vírus Epstein-Barr
/
Linfonodos
Tipo de estudo:
Estudo de prevalência
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Pak. J. Med. Sci.
Ano de publicação:
2008
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