Identifying isolated impaired glucose tolerance using common clinical data Tehran lipid and glucose study

ABSTRACT

To determine the clinical traits of subjects with isolated impaired glucose tolerance [isolated-IGT] defined as fasting plasma glucose [FPG]<100 mg/dl and 2-hour plasma glucose [2h-PG] between 140 mg/dl and 200 mg/dl. In this cross-sectional study, we evaluated the data and results of oral glucose tolerance test [OGTT] from 8212 participants of the Tehran Lipid and Glucose Study [4742 women and 3470 men] aged >/= 20 years, without diabetes. Logistic regression models for having isolated-IGT were developed among 7012 subjects with FPG<100 mg/dl to predict isolated-IGT. The overall prevalence of IGT was 13.6% [n=1120] of these subjects, 59.6% [n=668] were isolated-IGT. In the clinical model, the adjusted odds ratios [OR] for having isolated-IGT were statistically significant for age >/= 40 years [2.6], hypertension [1.9], overweight [1.7] or obesity [2.2], family history of diabetes [1.3], and female gender [1.2]. Adding the lipid profiles to the clinical model increased the area under the receiver-operating characteristics curve [AUC] only slightly [72.5% vs. 71.4%, P=0.001]. The other clinical model including waist circumference had similar predictive power compared to the clinical This analysis showed that in Tehranian adults with FPG<100 mg/dl, female gender, older age, family history of diabetes, overweight and obesity, and hypertension were significantly associated with a higher likelihood of isolated-IGT OGTT should hence be recommended in subjects with the above mentioned characteristics