[ Effect of Di-[2-Ethylhexyl] Phthalate [DEHP] on Mouse Daily Sperm Production and Epididymal Sperm Parameters]
Journal of Iranian Anatomical Sciences. 2009; 6 (25-26): 569-578
em Persa
| IMEMR
| ID: emr-91767
ABSTRACT
The purpose of tins study is to evaluate the effect of Di-[2-ethylhexyl] phthalate [DEHP] ontesticular spermatid number per gram testis [TSN]. daily sperm production [DSP], count, motility, viability morphology, and chromatine quality of epididymal sperm. The protocol for DEHP administration was [hat adult male NMRI mice [the age group or 4 weeks] received 2g DEHP/100ul corn oil/kg, and vehicle group received l00uI corn oil/kg by gavage for 14 days. The control group did not receive DEHP. All the salliples were assessed according to World Health Organization [WHO] criteria. Sperm morphology was assessed using papanicula staining Sperm chromatine quality was assessed using aniline-blue staning Results:
Administration of DEHP induced significantly reduction of TSN, DSP and epididymal sperm count [p < 0.05]. The percentage of motility, viability, normal morphology, and chromosomal quality were significantly low in comparison with control group [p < 0.05]. These results demonstrated that DEHP administration has toxic effects on TSN, DEP. Epididymal sperm parameter and finally on male reproductive system
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Motilidade dos Espermatozoides
/
Dietilexilftalato
/
Camundongos
Limite:
Animais
Idioma:
Persa
Revista:
J. Iran. Anat. Sci.
Ano de publicação:
2009
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