Ameliorative effects of whole soybean and oat grains in adrenaline-induced dyslipidemia

ABSTRACT

This investigation was planned to clarify the anti-dyslipidemic therapeutic effects of a food product containing soybean and/or oat grains in experimental dyslipidemia. A total of 35 adult male albino rats were divided into five groups, normal control, dyslipidemic control, dyslipidemic experimental group fed with soybean product, dyslipidemic experimental group fed with oat grains product and dyslipidemic experimental group fed with the two products in combination Dyslipidemia was induced to rats by injection intraperitonealy with adrenaline. After 30 days of treatment with the plant products, data analysis revealed that there were highly significant increases in the serum concentrations of total cholesterol, low-density lipoprotein [LDL] cholesterol and triglycerides in the dyslipidemic group compared with the normal group. On the other hand, High-density lipoprotein [HDL] cholesterol concentration was highly significantly decreased. Administration of soybean product exhibited a significant decreasing effect on serum total cholesterol and LDL cholesterol concentrations, a significant increasing effect on serum HDL cholesterol level and an obvious improvement in serum triglycerides level which was not statistically significant. Treatment with oat grains containing product showed highly significant decreasing effect on the serum level of total cholesterol, non- significant improvement in LDL cholesterol concentration, a significant increasing effect on serum HDL cholesterol level and non- significant decreasing effect on the level of triglycerides. Administration of the two products in combination exhibited a significant decreasing action on total cholesterol concentration, a highly significant modulation in the impaired LDL cholesterol level, a highly significant increasing effect on serum I-1DL cholesterol level and a significant reduction in triglycerides level as compared with the dyslipidemic control group. The current data demonstrated that regular consumption of whole soybean and oat grains products exhibited marked anti-dyslipidemic modulatory actions on the impaire4 serum lipid and lipoprotein profiles in adrenaline-induced experimental dyslipidemia. Generally, the effect of the two products in combination was more effective than the effect of cacti of them alone