Salivary levels of tumor necrosis factor-alpha in generalized periodontitis - a pilot study
JPDA-Journal of the Pakistan Dental Association. 2009; 18 (1): 22-23
em Inglês
| IMEMR
| ID: emr-92012
ABSTRACT
Periodontitis is usually a painless, slowly progressing infectious disease in tooth supporting tissues. The main etiological agents in periodontitis are dental plaque bacteria, especially gram negative micro organisms. The objective of the present study was to evaluate whether the salivary TNF-alpha concentration affect the periodontitis. Salivary tumor necrosis factor alpha levels were estimated in 25 patients with periodontitis and ten healthy normal. Concentrations of TNF-alpha wre determined using the human TNF-alpha ELISA kit [SIGMA ImmunoChemicals St. Louis, Mo, USA]. Significantly higher levels of Salivary tumor necrosis factor alpha were observed in periodontitis patients as compared to controls [p<0.001]. Saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity. Salivary TNF-alpha analysis may be a useful diagnostic tool and a potential prognostic marker in periodontal disease
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Periodontite
/
Saliva
/
Ensaio de Imunoadsorção Enzimática
/
Projetos Piloto
/
Placa Dentária
/
Bactérias Gram-Negativas
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Pak. Dent. Assoc.
Ano de publicação:
2009
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