Paget's disease scintgraphy and hormonal treatment

ABSTRACT

Pagetr's Disease is an intense osteoclastic resorption of bone followed by intense osteoblastic activity accompanied by intense vascularity replacement of normal lamellar bone with connective tissue with a significant in mature collagen content and subperiosteal new bone formation resulting in the characteristic cortical thickening. Pagefs disease can cause pain in the bones or joints, headaches and hearing loss, pressure on nerves, increased head size, bowing of limb, or curvature of spine. Tests used to diagnose Paget's disease include X-ray, blood and urine tests and bone scanning. The recommended treatment, in addition to receiving 1000-1500 mg of calcium, adequate sunshine, ca400 units of vitamin D daily, are the bisphosphonates and calcitouin which need to be monitored by hormonal analysis within the treatment period, also serum alkaline phosphatase [SAP] level in the blood is important in monitoring the progress of treatment