Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes
Saudi Medical Journal. 2009; 30 (3): 334-339
em Inglês
| IMEMR
| ID: emr-92651
ABSTRACT
To examined whether serum paraoxonase [PON1] and arylesterase [ARE] activities are correlated with inflammatory biomarkers [procalcitonin and high sensitivity C-reactive protein [hs-CRP] in patients with acute coronary syndrome [ACS]. This cross-sectional study was conducted at the Departments of Cardiology and Biochemistry, Uludag University School of Medicine, Bursa, Turkey, from April 2007 to December 2007. Seventy-eight consecutive patients with ACS and 39 healthy controls were investigated. Acute coronary syndrome patients were divided into 3 groups according to their clinical presentation unstable angina pectoris [UAP] [Braunwald III-B, n=25], non-ST elevation myocardial infarction [NSTEMI] [n=18], and ST-elevation myocardial infarction [STEMI] [n=35]. Serum PON1/ARE activities were measured spectrophotometrically. Levels of procalcitonin and hs-CRP were measured by immunoassay. Paraoxonase/ARE activities were significantly lower in all patient groups compared to controls. No correlation between PON1/ARE activities and high-density-cholesterol levels was seen. Among ACS patients, serum ARE activity correlated inversely with baseline and 48-hour procalcitonin [r=-0.577, p=0.009, and r=-0.642, p=0.019] and hs-CRP levels [r=-0.614, p=0.03, and r=-0.719, p=0.044]. Serum ARE activity is reduced in ACS patients and inversely correlated with inflammatory markers
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Proteína C-Reativa
/
Proteínas de Fase Aguda
/
Estudos Transversais
/
Estresse Oxidativo
/
Arildialquilfosfatase
/
Síndrome Coronariana Aguda
/
Angina Instável
/
Infarto do Miocárdio
Tipo de estudo:
Estudo de prevalência
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Saudi Med. J.
Ano de publicação:
2009
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