Successful treatment of chronic hepatitis C virus infection with peginterferon alpha-2a and ribavirin in patients with sickle cell disease
Saudi Medical Journal. 2009; 30 (5): 712-716
em Inglês
| IMEMR
| ID: emr-92732
ABSTRACT
The objective of this case series was to determine the efficacy and safety of combined treatment with ribavirin and peginterferon alpha-2a in sickle cell disease [SCD] patients with chronic hepatitis C virus [HCV] hepatitis. Eight patients in King Abdulaziz Hospital and Oncology Center, Jeddah, Kingdom of Saudi Arabia from 2003 and 2006 with chronic HCV infection were treated with peginterferon alpha-2a and ribavirin for one year. All 8 patients had a complete early virological response. Seven out of 8 had an end of treatment response with undetectable HCV RNA at the end of therapy, 5 of whom also maintained a sustained virological response when assessed 6 months after the end of treatment. Hemoglobin concentrations measured at one, 3, 6, 9, and 12 months of treatment showed no significant changes from that measured as baseline. Treatment of chronic HCV hepatitis in patients with SCD with peginterferon alpha-2a and ribavirin seems safe and effective
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ribavirina
/
Hemoglobinas
/
Resultado do Tratamento
/
Gerenciamento Clínico
/
Quimioterapia Combinada
/
Anemia Falciforme
Tipo de estudo:
Relato de Casos
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Saudi Med. J.
Ano de publicação:
2009
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