Effect of eicosapentaenoic acid [EPA] and vitamin e on the blood levels of inflammatory markers, antioxidant enzymes, and lipid peroxidation in iranian basketball players
Iranian Journal of Public Health. 2010; 39 (1): 15-21
em Inglês
| IMEMR
| ID: emr-93122
ABSTRACT
Exercise can change the release of numerous cytokines and modulate their receptor systems. Dietary w-3 lipids may decrease the levels of inflammatory cytokines and prostaglandins [PGs]. Therefore, in this study, we investigated the effects of exercise and eicosapentaenoic acid [EPA] supplementation, with or without vitamin E, on the blood levels of IL-2, TNF-alpha catalase, glutathione reductase, and MDA in male basketball players. Thirty-four well-trained male basketball players were enrolled into the study. Venous blood samples were obtained from all subjects between 500 and 600 p.m., after intensive endurance exercising for 2 hours, at the baseline and after intervention. Subjects received 2g EPA and/or 400 IU vitamin E or placebo depends on their groups for 6 weeks. There were significant fall [paired /-test] in TNF-a in groupl [P< 0.05], and in MDA in group 3 [P<0.05], whereas there were significant increase in glutathione reductase in groups 1 and 3 [P< 0.05], and in MDA in group2 [P< 0.05].There were significant differences [Tukey] in glutathione reductase between groups 2 and 3 [P< 0.05], and in IL-2 between groups 1 and other groups [P< 0.01], but there were no significant differences in MDA, CAT, and TNF-a, among groups after 6 week of intervention. Six weeks of EPA+vitamin E supplementation enhances the plasma levels of IL-2 and erythrocytes glutathione reductase, whereas it reduces TNF-alpha, and 6 weeks of EPA supplementation alone enhances only the serum level of MDA
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Basquetebol
/
Peroxidação de Lipídeos
/
Método Duplo-Cego
/
Interleucina-2
/
Fator de Necrose Tumoral alfa
/
Tocoferóis
/
Antioxidantes
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Adolescente
/
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Iran. J. Public Health
Ano de publicação:
2010
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