Treatment of toxic epidermal necrolysis [TEN] with low dose intravenous immunoglobulin in child

ABSTRACT

Stevens-Johnson syndrome [SJS] and toxic epidermal necrolysis [TEN, LyeII's disease] are severe, episodic, acute mucocutaneous reaction that may be caused by various factors particularly drugs. Treatment is primarily supportive care and there are no specific therapy regimens. Intravenous immunoglobulin [IVIG] has recently been shown to be a useful and safe therapy in paediatric patients with SJS/TEN, though no such case has so far been reported from Pakistan. The authors report the experience with low dose IVIG [0.1 g/kg/day for four consecutive days for treating a 3 years old boy with toxic epidermal necrolysis with favourable outcome without early complications