Immunomodulatory effects of zerumbone isolated from roots of zingiber zerumbet
Pakistan Journal of Pharmaceutical Sciences. 2010; 23 (1): 75-82
em Inglês
| IMEMR
| ID: emr-93411
ABSTRACT
In this study, the immunomodulatory effects of zerumbone isolated from Zingiber zerumbet were investigated by evaluating the effects of this compound towards the lymphocytes proliferation [mice thymocytes, mice splenocytes and human human peripheral blood mononuclear cells, PBMC], cell cycle progression and cytokirie [interleukin 2 and 12] induction. Lymphocyte proliferation assay showed that zerumbone was able to activate mice thymocytes, splenocytes and PBMC at dosage dependent pattern where the best concentration was 7.5 micro g/mL. Flow cytometry analysis showed the highest population of PBMC entered into G2/M phase after treatment for 72 h with 7.5 micro g/mL zerumbone. The production of human interleukin-2 and human interleukin-12 cytokines in culture supernatant from zerumbone activated lymphocytes was prominently upregulated at 24 hour and decreased from 48 h to 72 h. The above results indicate that zerumbone can be used as immunomodulatory agent which can react toward the immune cell cytokine production in dosage dependent pattern
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Sesquiterpenos
/
Raízes de Plantas
/
Avaliação Pré-Clínica de Medicamentos
/
Fatores Imunológicos
/
Camundongos
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2010
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