Evaluation of cardiac risk by oxidative stress and inflammatory markers in diabetic patients
Pakistan Journal of Medical Sciences. 2009; 25 (5): 776-781
em Inglês
| IMEMR
| ID: emr-93609
ABSTRACT
To evaluate the diabetic patients for cardiac risk by measuring oxidative stress and inflammatory markers in relation with glycaemic control. A total of 140 subjects were included in this case-control study, comprising of 70 diabetic patients with coronary heart disease [CHD] and an equal number, age and sex matched controls. The patients were non-alcoholic and had age >40years, BMI < 30 kg/m2 and glycated hemoglobin [HbA1c] 7-10%. Serum total cholesterol [TC] and gamma glutamyltransferase [GGT] were analyzed on selectra-E auto analyzer. Serum nitrate was measured at 540nm on ELISA. HbA1c on was analyzed by using Human kit. Serum high sensitivity C-reactive protein [hS-CRP] was analyzed on immulite 1000. Patients mean age was 51 [range 40-73] years. Diabetic patients had significantly elevated median of HbA1c [7.9 vs 4.9], hS CRP [6.0 vs 2.12], TC [5.95 vs 4.45], nitrate [19.20vs 10.70] and GGT [29.50 vs 22.50] as compared to controls [p< 0.001]. HbA1c showed a positive correlation [p <0.001] with hS-CRP [r=0.49], TC [r=0.69], nitrate [r=0.41] and GGT [r=0.30]. Oxidative stress and inflammatory markers should be used in addition to HbA1c for assessment of increased cardiac risk in un-controlled diabetic patients because of accelerated atherosclerosis due to free radical injury
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Hemoglobinas Glicadas
/
Biomarcadores
/
Estudos de Casos e Controles
/
Estresse Oxidativo
/
Doença das Coronárias
/
Estudo de Avaliação
/
Aterosclerose
/
Inflamação
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Pak. J. Med. Sci.
Ano de publicação:
2009
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