Survival models in breast cancer patients

ABSTRACT

Breast cancer is the most prevalent malignancy among Iranian women. Five and ten year survival is one of the indicators used for evaluation of the quality of care after surgery. In this study, we used several survival models to determine risk factors, survival times and life expectancies of different types of surgery. This study was performed on 310 patients who underwent surgery during a ten years period. Logistic regression and Cox regression models were used to analyze the factors leading to death. The Kaplan-Meier method [non-parametric] was used to estimate the survival rate. The log-rank test was used to compare survival in different groups. To compare life expectancy of different types of surgery, we used the actuarial life table method. Logistic regression showed that stage, grade, age and history of benign malignancy had significant relationship with death. Log-rank test showed that there was a significant difference between survival for patients with different stages, age and history of benign tumors. Cox regression model demonstrated that the variables of stage, grade, age and benign problems were the major risk factors. Actuarial life table model showed that the life expectancy for all patients was 10.03 years. This life expectancy in early stages of breast cancer for mastectomy and lumpectomy were 8.99 and 8.35 years, respectively, which was not significant. It can be concluded that the higher stage, grade, age and history of benign tumor were, the most important risk factors were correlated to mortality in breast cancer patients. This study showed that there was no significant difference between life expectancies of mastectomy and lumpectomy surgery