Anti-hepatotoxic effect of pterocephalus sanctus growing in Egypt
Journal of the Arab Society for Medical Research. 2008; 3 (1): 83-87
em Inglês
| IMEMR
| ID: emr-94495
ABSTRACT
Pterocephalus sanctus Decne. was subjected to a bioassay guided fractionation in order to follow and identify the active principles that could be responsible for its anti-hepatotoxic property. The aqueous methanol [80%] extract of the defatted powder of Pterocephalus sanctus was chromatographed over silica gel and eluted with gradient petroleum ether/ethyl acetate. Eight fractions were collected and tested for their biological activity using Primary Cultured Monolayer Hepatocytes where the fifth fraction was subjected to a further fractionation. Three compounds were identified as secologanin, loganin and swerosoid and the latter was only found to possess highly anti-hepatotoxic activity. This is the first report of the study of the anti-hepatotoxic activity of P. sanctus growing in Egypt
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos
/
Extratos Vegetais
/
Substâncias Protetoras
/
Modelos Animais
/
Dipsacaceae
Limite:
Animais
Idioma:
Inglês
Revista:
J. Arab Soc. Med. Res.
Ano de publicação:
2008
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