new spectrum for cancer chemotherapy toxicity

The charts of 480 patients with different malignancies who were treated by different chemotherapeutic regimines in unit B, department of Surgery, Alexandria University Hospitals were reviewed. Five patients suffered lethal cardiac toxicities while only two showed the manifestations of paralytic ileus. The action of some of the commonly used chemotherapeutics on the frog's heart and rabbit's intestine were demonstrated experimentally. This was done in a trial to ellucidate and verify the toxic effects of these drugs in humans