Gestational trophoblastic disease a study

ABSTRACT

A total of 27 cases of Gestational Trophoblastic Disease [GTD] including 24 of hydatidiform mole and 3 of choriocarcinoma were seen during a three year period. During this time, 5702 pregnant patients were admitted giving a rate per pregnancy of 1211 or 4.74 per 1000. Of the 27 cases, 9 [33.33%] mothers and 12 [44.44%] fathers were 40 years or over in age. Nineteen women [70.37%] were gravida 5 or over. No relation to specific dietary factors, age of menarche, contraception, blood groups or weight was elicited. No patient had pre-eclampsia, thyrotoxicosis or disseminated intravascular coagulation. Only one patient had excessive vomiting. None had metastatic disease. Twenty-two [81. 48%] patients were anaemic, and 15 [55.55%] required at least two units of blood transfusion. Of patients with hydatidiform mole 16 [59.26%] had primary suction curettage, 7D and C and 1 primary hysterectomy. Later, 1 patient with residual GTD required methotrexate, and another a hysterectomy. The three cases of choriocarcinoma were diagnosed on diagnostic D and C and were given MAC regimen. One later required a hysterectomy. Monitoring and follow-up of all except first five cases of GTD was done by serial serum beta HCG levels