Study of antimutagenic and mutagenic effect of different chemicals on clinically isolated strains of pseudomonas aeruginosa

ABSTRACT

This project was undertaken to study the effect of twelve different compounds to test their antimutagenic and ii mutagenic activity against clinically isolated strains of Pseudomonas aeruginosa. The effect of these compound was estimated by counting the number of rifampicin resistant colonies growing in a particular time in a it compound. The results were interpreted by plotting graphs between lOg N/No [Rif R Colonies/ml] and time to estimate the forward mutation rate. The results revealed that Acridine, Basic fuchsin, Caffeine, Cyclohexamide, Zehidium bromide and Histidine probably have an antimutagenic effect, while [steine, Folic acid, Ethyl-methane. ulphonate, Manganous Chloride and N-nitrosodietylamine acted as mutagen. E.coli was used as control through out the study