[Drug interaction between iron and oxytetracycline absorption in swine]

ABSTRACT

Iron is known to interfere with the absorption of simultaneously taken tetracycline derivatives. In order to avoid this interaction a suitable time interval should be regarded between the administration of tetracycline and iron in swine. The drug interaction is probably due to the formation of chelates in the gastrointestinal tract. A time interval of about 3 hours however is sufficient to avoid drug interaction between iron and tetracyclines. The present study was intended to demonstrate the interference between iron [in rusty water] and oxytetracydine absorption in swine. But the amount and/or the type of iron used, may not significantly influence the absorption of simultaneously ingested tetracycline