Effect of vitamins A, E, C and omega-3 fatty acids on lipid peroxidation in streptozotocin induced diabetic rats

ABSTRACT

To assess the effect of supplementation with vitamins A, E and C and omega-3 fatty acids on lipid peroxidation in Streptozotocin [STZ] induced diabetic rats. Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, diabetic with vitamin A, E as well as C supplementation and diabetic with omega-3 fatty acids supplementation. After four weeks of treatment the rats were anesthetized and malondialdehyde [MDA] levels were investigated in blood samples, liver and heart homogenate. In diabetic rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats [P< 0.05]. Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA [P< 0.05]. A significant decrease in heart MDA [P< 0.05] was observed in diabetic rats with omega-3 fatty acids supplementation. Supplementation of vitamin A, E and C and co-3 fatty acids was found to decrease lipid peroxidation to some extent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes