Association of the UCP2 -866G/A polymorphism with type 2 diabetes and obesity in Saudi population

ABSTRACT

Diabetes mellitus is emerging as a major public health problem allover the world particularly Saudi Arabia. Recent studies reported that Uncoupling Protein 2 [UCP2] was associated with obesity and type 2 diabetes [T2D]. This study was conducted to clarify the contribution of polymorphism in UCP2 in obesity and T2D in the Saudi population. The distribution of the-866G/A polymorphism was examined in a case-control study including samples from 110 obese patients, 81 T2D patients, 96 obese-T2D patients and 100 healthy unrelated Saudi subjects. The-866G/A polymorphism were determined by using PCR/RFLP [polymerase chain reaction/restriction fragment length polymorphism] techniques. The results of this study showed that the frequency of the GG genotype was significantly higher in both obese and T2D patients [p-value= 0.000 1, p-value= 0.0 14, respectively] compared with healthy control. The G allele was significantly associated with increase risk of obesity [odd ratio, OR 3.3; 95% confidence interval, CI 1.37-7.98], but not with T2D [OR, 1.97; C1, 0.80-4.87]. In obese-T2D patients group, no significant correlation with-866G/A polymorphism [p= 0.067; OR, 1.21; C1, 0.25-2.80]. This unreeled study suggested that the G allele of UCP2-866G/A polymorphism was related to obesity, which indicated the possible role of this polymorphism in causing metabolic syndrome. This study concluded that the G allele of UCP2-866G/A polymorphism might be related to obesity and T2D which might be used as a predictive marker for obesity and T2D