Yq microdeletion in men with severe impairment of spermatogenesis undergoing intra cytoplasmic sperm injection

ABSTRACT

Genetic aberration is an important etiological factor in infertile male. Among these microdeletion of the long arm of the Y chromosome is the most common. The aim of this study was to check the incidence and the type of microdeletion in men with severe impairment of spermatogenesis and the relationship between these deletions and the ICSI procedure. Three hundred and ninety male were recruited to this study. The incidence of the microdeletion was 4% in patients with severe oligospermia and 8.5% in azoospermia patients. Deletion in AZFc region was the most common type of deletion encountered the degree of impairment of spermatogenesis was related to the size of the deletion rather than the type of the deletion. Sperm recovery in patients with microdeletion was less than those without deletion. Fertilization and pregnancy rate were comparable to genetically free couples. We conclude that microdeletion have negative effect on spermatogenesis depending on the size of the deletion bur not on the sperm quality