Study on HLA-DQB1,03 allele associated with women human papilloma virus [HPV] lesions

ABSTRACT

The specific HLA alleles associated with HPV differ among various study groups. It has been suggested that women carrying HLA-DQw3 antigen encoded by DQB 103, are predisposed to develop cervical cancer. The aim of this study was to determine HLA-DQB103 alleles in HPV lesions. In a cross-sectional and analytical study, Hundred women enrolled into the study. Twenty of them had abnormal Pap smear, Fifty patients had condyloma lesions and 30 patients with malignant lesions. HLA-DQB03 and HPV infection was evaluated by PCR. PCR of HPV was positive in 50 women with condyloma lesions and 8 women with malignant lesion [p< 0.001]. HLA-DQB03 was positive in 9 women with abnormal Pap smear, 18 women with condyloma lesions and 7 women with malignant lesion[P= 0.261]. Positive PCR of HPV was significantly higher in women with condyloma lesions than other women [p< 0.001]. Mean age of patients with positive PCR of HPV was significantly lower than patients with negative PCR of HPV [P= 0.001]. Mean age of patients with positive HLA-DQB03 was 42.08 + 11.48 year and mean age of patients with negative HLA-DQB03 Was 43.83 +11.21 year [P= 0.462]. HLA-DQB03 was positive in 34% of patients. In this study, we do not see any significant correlation between HPV infection and HLA-DQB03 in the studied women