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Recombinant activated factor VII in controlling bleeding in non-hemophiliac patients
Annals of Saudi Medicine. 2010; 30 (3): 198-202
em Inglês | IMEMR | ID: emr-98761
ABSTRACT
There have been recent reports on the successful use of recombinant factor Vila [rFVIIa] in non-hemophiliac patients who have experienced heavy blood loss due to trauma with extensive organ damage and who have received multiple blood transfusions with hemostatic changes without success. The timing of administration, dosage, mortality, units of blood transfusion saved, risk of thrombotic events, and the risk/benefit ratio are still poorly defined. We conducted a retrospective review of all medical records of patients who received rFVIIa between January 2003 and March 2008. Data collection included demographic characteristics, diagnosis, indications, comorbidities, and amount of blood products used with rFVIIa, dose of rFVIIa, mortality, and adverse events. We identified 45 patients, 27 [60%] males and 18 [40%] females, with a median age of 52 years. The median dose of rFVIIa was 40 micro g/kg [range, 20-120 micro g/kg]. Five [11.1%] patients needed a second dose of rFVIIa [dose range of 20-85 micro g/kg] whereas three patients [6.7%] needed a third dose of rFVIIa [dose range of 40-60 micro g/kg]. There was a marked and significant reduction in transfusion requirements for packed red blood cells [P=.0078]. Overall transfusion requirements significantly decreased after the infusion of rFVIIa [P=.0323]. Nineteen patients [42.2%] died and thrombosis was documented in 3 patients [6.7%].Use of rFVIIa should be based on sound clinical evidence to balance the risks, benefits, and cost if used among non-hemophiliacs. Prospective randomized studies are needed to investigate the efficacy and cost-effectiveness of rFVIIa for this indication and to allow a final assessment of the importance of this treatment
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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Fator VIIa / Estudos Retrospectivos / Resultado do Tratamento / Hemorragia Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Ann. Saudi Med. Ano de publicação: 2010

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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Fator VIIa / Estudos Retrospectivos / Resultado do Tratamento / Hemorragia Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Ann. Saudi Med. Ano de publicação: 2010