Association of A1936/G Exon 11 polymorphism of thyroid peroxidase gene with anti-TPO levels in an Iranian population

ABSTRACT

Antibody secretion in human may be the result of the changes in protein structure, or polymorphism in human thyroid peroxidase [TPO] gene that are the reason for presence of the Anti TPO. In this study we examined the association between of A1936/G exon11 polymorphism of TPO gene in respect to Anti-TPO level and in a sample population of Tehran. We enrolled 190 individuals with 47 +/- 2 y an average age of case-control groups. PCR-ARMS was used to amplify the segment of exon11 polymorphisms. In exon 11, the genotype frequencies were in conformity with the Hardy-Weinberg expectation. The results of this study show that the frequencies were 0.7298 for the G allele and 0.2710 for A allele. The presence of the G allele is significantly associated with increased anti-TPO level [GG 238 +/- 57 IU/ml vs. AA 74 +/- 33 IU/ml, P<0.05]. The G allele frequenc in the group with anti-TPO>100, was higher than that of the A allele. The results indicated that G allele carriers of exon 11 are exposed to increased Anti-TPO levels higher than A carriers